Pawel Dydio and Joost Reek in Nature Protocols

13 May 2014

HIMS researchers Pawel Dydio and Joost Reek (Homogeneous, Supramolecular and Bio-inspired Catalysis) have published an article in Nature Protocols. They describe the synthesis of a bisphosphite ligand that is the pivotal element of their new catalytic system for the 100% regioselective and chemoselective synthesis of 2-(2-formylalkyl)-arenecarboxylic acid derivatives.

With their publication the HIMS researchers contribute to the preparation of common building blocks for the synthesis of various valuable chemicals, such as pharmaceuticals for the treatment of Alzheimer's disease and obesity. Their protocol concerns in particular the synthesis of 2-(2-formylalkyl)-arenecarboxylic acid derivatives by using the fully regioselective hydroformylation of vinyl arene derivatives. This catalytic reaction proceeds cleanly with 100% regioselectivity and chemoselectivity.

The procedure is reliably scalable and can be efficiently conducted on a multigram scale. The analytically pure product is easily isolated with a nearly quantitative yield by using a simple acid-base extraction workup and avoids any tedious chromatography. 

The main focus of the Nature Protocols publication is the synthesis, starting from commercial building blocks, of the bisphosphite ligand that is - in combination with Rh(acac)(CO)2  - the pivotal element of the catalytic system used.


Pawel Dydio & Joost N H Reek: Scalable and chromatography-free synthesis of 2-(2-formylalkyl)arenecarboxylic acid derivatives through the supramolecularly controlled hydroformylation of vinylarene-2-carboxylic acids. Nature Protocols Nature Protocols 9, 1183–1191 (2014). DOI:10.1038/nprot.2014.077 

Pawel Dydio

Pawel Dydio obtained his PhD cum laude on 22 November 2013 with Professor Joost Reek of the research group for Homogeneous, Supramolecular and Bio-inspired Catalysis. Dydio recently obtained a NWO Rubicon grant for his research with Professor John F. Hartwig at the University of California, Berkeley.

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Published by  HIMS